By Isabel Debre And Julia Frankel JERUSALEM (AP) — Israel launched a major attack on Iran Friday, drawing their long-running shadow war into open conflict in a way that could spiral into a wider, more dangerous regional war. The strikes set off explosions in the capital of Tehran as Israel said it was targeting Iranian nuclear and military facilities. Among those killed were three of Iran’s top military leaders, one who oversaw the entire armed forces, Gen. Mohammad Bagheri, one who led the paramilitary Revolutionary Guard, Gen. Hossein Salami, and another who ran the Guard’s ballistic missile program, Gen. Amir Ali Hajizadeh. Two top nuclear scientists also had been killed. Israel said it killed additional Revolutionary Guard members. Israel said Iran retaliated by sending over 100 drones toward Israel, most…